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Gilbert has appeared on The Simpsons, 24, Will & Grace, Law & Order: Special Victims Unit and Private Practice.
Starting in 2004, she had a recurring role as smart but sarcastic medical student Jane Figler on the long-running hospital drama ER; her appearances spanned seasons 11-13.
Winkle got discontinued after Amy Farrah Fowler and Bernadette Rostenkowski became prominent characters.
When asked if she was comfortable being 'out' on The Talk, she said at the time: 'This is a whole new world for me.Gilbert, who created the CBS daytime show, split from Adler after ten years in August.Co-host Julie Chen prompted Gilbert's teary admission on Friday when she asked, "Is marriage all it's cracked out to be?Gilbert also had a feature role in Light It Up in 1999.
She has had several minor roles following Roseanne, including the short film (aka 30 Bucks) as part of the Boys Life 3 feature, and High Fidelity.
Sara was a cast member in the show's nine-year run (1988–97), for which she wrote a fourth-season episode story (the teleplay was written by the Guild Writers for the show) called "Don't Make Me Over".